Axis Labs PHIRE! is a revolutionary pharmaceutical-grade fat loss formula specifically designed to boost your metabolism and heighten your energy levels. PHIRE's scientifically designed mixture of ingredients are brought together as a powerhouse team to eradicate undesired fat where it matters most! Ground breaking ingredients such as Evodiamine and Forskolin have been shown to utilize stored body fat for energy, naturally increasing the body's metabolism. In addition, PHIRE! is formulated with Caffeine, Yohimbe and Tyrosine to increase energy, mental alertness and focus. Stop spinning your wheels with inefficient fat loss products and upgrade to Axis Labs PHIRE!, the Xtreme Metabolic that will make you forget all about ephedra. Get PHIRE! now to help you expose your hardest core ever! Product Highlights: Powerful Source of Energy and Increases Mental Alertness and Focus Decreases Fatigue Maintains Muscle Tone Utilizes Stored Body Fat for Fuel Optimizes Cardiovascular Function [increases capillary dilation] Suppresses Appetite Supports Energy Metabolism and Helps the Body with the Breakdown of Fat and Carbohydrates Supports Thyroid Production to Ramp Up Metabolism Enhanced Feeling of Well Being Enhanced Insulin Secretion and Sensitivity What is PHIRE! made up of that makes it such a powerful fat burning supplement? Evodiamine Evodiamine is a bioactive alkaloid extract from a plant called Evodiae Fructus. This is a Chinese herb named Wu-Chu-Yu that Chinese herbalists have used for centuries as a weight loss supplement. Evodiamine is related to capsaicin or the spicy flavor of peppers. It acts as a vanilloid receptor agonist, and can enhance lipolytic (breakdown of fat) activity, enhance insulin secretion and sensitivity. Interestingly enough, Evodiamine can raise the body's skin temperature while simultaneously decreasing core temperature, similar to a hypothermic state. Studies have shown that this is an effective process to burn calories and fat for energy while the body increases its temperature. Forskolin Froskolin is a diterpene found in the root of an Indian plant called Coleus Forskohlii (part of the mint family of plants). In the body, Forskolin activates an enzyme that raises levels of a key cell-regulating substance called cAMP (cyclic adenosine monophosphate). Increased cellular cAMP levels cause numerous physiological and biochemical effects such as increased insulin secretion, increased thyroid function (and therefore metabolic rate), reduced adipose assimilation and increased lipolysis (the breakdown of fats). Forskolin can also increase blood flow and capillary dilation. Thiamine Thiaming helps support energy metabolism and assists the body with the breakdown of fat, and carbohydrates. Every cell of the body requires vitamin B1 to form ATP from the break down of fat and carbohydrates. Thiamine keeps your mucous membranes healthy and is essential for nervous system, cardiovascular and muscular function, and it also helps maintain muscle tone. Niacin Niacin helps support energy metabolism and assists the body with the breakdown of fat, carbohydrates. Niacin helps fuel your body by converting blood sugar into energy, and assists in the release of energy from the metabolism of carbohydrates, fats, and proteins. Niacin is also necessary for the synthesis of secondary sex hormones. Yohimbine Yohimbine, an alkaloid, is the primary active ingredient of yohimbe. Yohimbine increases the amount of adrenergic activity in the body, increasing levels of norepinephrine and stimulation of the central nervous system. In addition, Yohimbine has shown to increase lipolysis (the breaking down of fat). Yohimbine has also shown to be an appetite suppressant, potentially reducing caloric intake. It has also been shown to enhance insulin secretion and sensitivity. Caffeine Caffine has Thermogenic properties and increases lipolysis (fat break down). Caffine can suppress appetite, decrease fatigue, and increase alertness and work capacity, which can be very beneficial for endurance exercise. Caffine acts as a stimulant and has a synergistic effect with norepinephrine and other catecholamines like ephedrine and possibly yohimbine. Thermogenic and stimulant effects can be greatly increased through the synergistic effect of caffine. L-Tyrosine L-Tyrosine is essential amino acid that is a building block of protein and is necessary for maintaining proper brain function. L-Tyrosine is a precursor to the adrenal hormones norepinephrine, epinephrine, dopamine and to thyroid hormones. Because L-Tyrosine is a precursor of dopamine, supplementing with L-Tyrosine may increase feelings of well being, heighten mental alertness and offset physical and mental fatigue. L-Tyrosine has also show to suppress appetite, potentially reducing caloric intake. Supplement Facts Serving Size: 2 Mini-Caps Servings per Container: 60 Amount Per Serving *%DV Vitamin B1 (Thiamine) 25mg 1666% Vitamin B3 (Niacin) 25mg 125% Caffeine Anhydrous 200mg + Yohimbe (3% Yohimbine) 100mg + Evodiamine 98% 50mg + Coleus Forskohli (40% Forskolin) 50mg + L-Tyrosine 50mg + *Daily value (DV) are based on a 2000 calorie diet +Daily value (DV) not established Other Ingredients: Dicalcium Phosphate, Gelatin, purified water, Magnesium Stearate, Silica. Directions: As a dietary supplement, take 1-2 capsules, 30 minutes prior to breakfast and 1-2 capsules in the early afternoon. Do not take 6 hours prior to bed because PHIRE!T may interfere with sleep. For best results, use in conjunction with a reduced caloric diet and cardiovascular exercise program. Store in a cool place. Protect from heat, light and moisture. WARNING: KEEP OUT OF REACH OF CHILDREN. Not for use by individuals under the age of 18 or elderly. Consult a physician before using this or any dietary supplements. Do not use if pregnant, nursing or chronically ill. This product is not intended for individuals who are at risk of or have been treated for high blood pressure, heart disease, thyroid disease, depression or other psychiatric condition, renal disease, reoccurring headaches, spasms, has asthma or taking asthma medication or if your are using a MAO inhibitor. Manufactured with pride in the USA. PHIRE is a registered trademark of Axis LabsT REFRENCES: Evodiamine 1) Kobayashi, Y., Y. Nakano, M. Kizaki, K. Hoshikuma, Y. Yokoo and T. Kamiya (2001). Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med 67(7): 628-33. 2) Komatsu, K., K. Wakame and Y. Kano (1993). Pharmacological properties of galenical preparation. XVI. Pharmacokinetics of evodiamine and the metabolite in rats. Biol Pharm Bull 16(9): 935-8. 3) Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM. (2004). Evodiamine functions as an agonist for the vanilloid receptor TRPV1. Org Biomol Chem. Aug 21;2(16):2281-6. Epub 2004 Jul 27. 4) Tsai, T. H., T. F. Lee, C. F. Chen and L. C. Wang (1995). Thermoregulatory effects of alkaloids isolated from Wu-chu-yu in afebrile and febrile rats. Pharmacol Biochem Behav 50(2): 293-8. Tyrosine 5) Banderet, LE, and Lieberman HR. (1989). Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull 22: 759-762. 6) Gelenberg AJ, Gibson CJ, Wojcik JD. (1982). Neurotransmitter precursors for the treatment of depression. Psychopharmacol Bull 18:7-18. 7) Harmer CJ, McTavish SF, Clark L, Goodwin GM, Cowen PJ. (2001). Tyrosine depletion attenuates dopamine function in healthy volunteers. Psychopharmacology (Berl). Feb;154(1):105-11. 8) Hull KM, Maher TJ. (1990). L-tyrosine potentiates the anorexia induced by mixed-acting sympathomimetic drugs in hyperphagic rats. J Pharmacol Exp Ther. Nov;255(2):403-9. 9) Lieberman, HR, Corkin S, Spring BJ, Wurtman RJ, and Growden JH. (1985). The effects of dietary neurotransmitter precursors on .
