SAMe is a supplement formed in the body by an enzymatic reaction between adenosine-triphosphate (ATP) and methionine. It was discovered in 1952 in Italy and has been researched and manufactured there. SAMe works closely with folic acid and vitamin B-12 and functions as a methyl donor. This nutrient carries and donates methyl molecules necessary to facilitate the manufacture of DNA and brain neurotransmitters. * Tissue levels of SAMe are typically low in the elderly. Details Serving Size: 1 Tablet Suggested Use: As a dietary supplement, take 1 tablet daily, preferably on an empty stomach. Refrigeration is recommended after opening. Free of: Yeast, corn, soy, wheat, milk, gluten, preservatives, additives. Other Ingredients: Cellulose, Mannitol, Hydroxypropyl Methylcellulose Phthalate, Citric Acid,Sodium Starch Glucolate, Glyceryl Triacetate,Croscarmellose Sodium, Stearic Acid, Silica. Warnings: Individuals with bipolar (manic) depression should not take SAMe unless under professional supervision. CAUTION: Please discard the inedible freshness packet enclosed. Disclaimers: *This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.<br /> .